What is TB-500?
TB-500 is a synthetic peptide derived from the actin-binding domain of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid protein distributed across virtually all human cell types. Thymosin Beta-4 plays a regulatory role in the organisation of the actin cytoskeleton — the internal scaffolding that governs cell shape, motility, and signalling.
The "TB-500" nomenclature in the research literature typically refers to a synthetic peptide spanning the core active region of Tβ4, particularly the LKKTETQ actin-binding domain, which is believed to be responsible for the protein's observed effects on cell migration, angiogenesis, and anti-inflammatory signalling in preclinical models.
ClaraScience supplies TB-500 as a lyophilised powder in 10mg vials. Each batch is independently HPLC-tested at a WHO/GMP-certified analytical laboratory and verified at ≥99.5% purity. A complete Certificate of Analysis (COA) including HPLC chromatogram and mass spectrometry identity confirmation accompanies every order.
Origin. Synthetic fragment based on the LKKTETQ actin-binding region of Thymosin Beta-4.
Mechanism studied. Actin polymerisation sequestration, cell migration facilitation, anti-inflammatory cytokine modulation in preclinical models.
Purity. ≥99.1% HPLC-verified. Full COA with every batch.
Research Background
The scientific study of Thymosin Beta-4 has been ongoing since its isolation in the early 1970s by Dr. Allan Goldstein and colleagues at George Washington University. Initial research focused on its role in T-cell maturation and immune function, with subsequent decades of investigation revealing its broader roles in cellular repair, wound healing, and angiogenesis.
A 2012 review by Goldstein AL et al. in Expert Opinion on Biological Therapy (12:37–51) summarised the extensive preclinical evidence for Tβ4's roles in tissue repair, with particular focus on cardiac, corneal, dermal, and musculoskeletal tissue models. Phase I and II clinical trials have been conducted for cardiac indications, with the peptide demonstrating a favourable safety profile in human subjects, though no therapeutic approval exists.
TB-500 is one of the most commonly studied research peptides in the preclinical tissue repair field and is frequently studied in combination with BPC-157, which operates through different but complementary cellular mechanisms. This combination has been observed in multiple rodent models studying tissue repair across different tissue compartments.
Key citation Goldstein AL et al. "Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications." Expert Opin Biol Ther. 2012;12(1):37–51.
Compound Specifications
| Common Name |
TB-500 (Thymosin Beta-4 fragment) |
| Structure |
43 amino acids · Thymosin β4 synthetic fragment |
| Molecular Weight |
4963.44 g/mol |
| Purity (HPLC) |
≥99.1% — independently verified |
| Vial Size |
10mg lyophilised powder |
| Storage (lyophilised) |
2–8°C (short-term) · −20°C (long-term) |
| Analytical Testing |
HPLC + Mass Spectrometry + Endotoxin |
| Primary Reference |
Goldstein AL et al., Expert Opin Biol Ther 2012;12:37–51 |
Storage & Handling Guidelines
TB-500 is supplied as a lyophilised powder for maximum stability during shipping and storage. All ClaraScience orders are shipped in plain, discreet packaging from our Australian warehouse.
- Unopened lyophilised vial: 2–8°C for regular use; −20°C for storage beyond 3 months.
- After reconstitution: Store at 2–8°C. Use within 28 days. Do not freeze reconstituted solution.
- Light sensitivity: Store away from direct light in the original sealed vial until use.
- Reconstitution: Use sterile bacteriostatic water. Use our free reconstitution calculator for the exact volume.
See our Storage & Handling Guide and Reconstitution Lab Guide for full laboratory protocols.
Ordering & Pricing — Australia
TB-500 is stocked and dispatched from our Australian warehouse. No customs risk, no international delays, full Australian Consumer Law coverage.
| Quantity |
Price per vial |
Saving |
| 1–4 vials |
$99.95 AUD |
— |
| 5–9 vials |
$89.95 AUD |
Save 10% |
| 10+ vials |
$79.95 AUD |
Save 20% |
Free priority tracked shipping on orders over $250 AUD. Dispatched within 24 hours of payment. For larger volumes, visit our wholesale enquiry page.
Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic peptide based on the actin-binding domain of Thymosin Beta-4, a naturally occurring protein involved in cytoskeletal organisation, cell migration, and wound healing signalling. It has been studied across numerous preclinical tissue repair models. All ClaraScience products are for laboratory research use only.
What is the difference between TB-500 and Thymosin Beta-4?
Thymosin Beta-4 (Tβ4) is the full 43-amino-acid endogenous protein. TB-500 is a synthetic peptide specifically replicating the core actin-binding region of Tβ4, which is believed to drive most of the observed biological activities studied in preclinical research. TB-500 is more widely available as a research compound than the full native protein.
Is TB-500 available in Australia?
ClaraScience supplies TB-500 as a research-grade peptide from an Australian warehouse. Products are for research use only and have not been evaluated or approved by the TGA for therapeutic purposes.
What purity is your TB-500?
ClaraScience TB-500 is independently HPLC-tested to ≥99.5% purity by a WHO/GMP-certified laboratory. A full COA including HPLC chromatogram and mass spectrometry identity confirmation is provided with every batch.
Should TB-500 be stacked with BPC-157?
TB-500 and BPC-157 are among the most co-studied compounds in preclinical tissue repair research due to their complementary mechanisms. TB-500 facilitates actin polymerisation and systemic cell migration; BPC-157 acts through localised growth factor and nitric oxide signalling pathways. Whether to research them together depends on your specific study protocol.
How long does shipping take in Australia?
Orders dispatch from our Australian warehouse within 24 hours of payment. Delivery typically takes 1–3 business days within Australia. All orders include tracked priority shipping. Orders over $250 AUD include free shipping.
