What is acetic acid water and when is it needed?
Most lyophilised peptides dissolve readily in bacteriostatic water. A minority — typically longer, more hydrophobic sequences, or peptides supplied as a salt that aggregates near neutral pH — remain hazy, form gel-like clumps, or precipitate. Lowering the pH with a small amount of dilute acetic acid protonates acidic side chains, increases net positive charge and breaks up aggregates, so the peptide goes into solution cleanly.
ClaraScience acetic acid water is a sterile 0.6% (v/v) acetic acid solution in water for reconstitution. It is used as a first-step solvent only: dissolve the peptide in a small volume of acetic acid water, then bring the vial to its final volume with bacteriostatic water so the working solution has the preservative and a near-neutral pH for storage.
In the ClaraScience range it is recommended for AOD-9604 and Tesamorelin; it is not needed for BPC-157, TB-500, Ipamorelin, CJC-1295 or the GLP-1 class peptides. For laboratory research use only.
Composition. Sterile water for reconstitution + 0.6% v/v glacial acetic acid (CH₃COOH).
Use. First-step solvent for hydrophobic or aggregation-prone peptides; then top up with bacteriostatic water.
Not for. Routine reconstitution of water-soluble peptides — use bacteriostatic water alone.
How to use acetic acid water
1. Dissolve. Swab both stoppers. Add a small volume of acetic acid water — typically 0.2–0.5mL for a 5–10mg vial — down the inside wall of the peptide vial. Swirl gently until the solution is completely clear. Do not shake.
2. Top up. Add bacteriostatic water to reach the final volume you calculated with the reconstitution calculator. The preservative in the bacteriostatic water is what allows multi-dose use; the acetic acid fraction is small enough that the final solution is only mildly acidic.
3. Check and store. The final solution should stay clear. If haze returns after topping up, the acid fraction was too small — start again with a slightly larger first-step volume. Label with the reconstitution date and store at 2–8°C; use within 28 days. Full method: Reconstitution Guide.
Reference Peptide solubility guidance: for peptides with net negative charge or high hydrophobicity that fail to dissolve in water, dissolve in a small volume of dilute (≤10%) acetic acid and dilute to volume; United States Pharmacopeia General Chapter <797> for sterile handling and beyond-use dating.
Specifications
| Product |
Acetic Acid Water 10mL |
| Composition |
Sterile water for reconstitution, 0.6% v/v acetic acid (CH₃COOH, 60.05 g/mol) |
| Grade |
Sterile, non-pyrogenic; USP-grade components |
| Vial |
10mL clear glass vial, rubber stopper, flip-off cap |
| pH |
≈3 (as supplied); near-neutral after dilution into bacteriostatic water |
| Use |
First-step solvent for hydrophobic peptides — AOD-9604, Tesamorelin |
| Storage |
Room temperature (15–30°C); do not freeze |
| Beyond-use |
Discard 28 days after first puncture |
Storage & Handling
- Unopened vial: room temperature, 15–30°C, protected from light. Do not freeze.
- After first puncture: swab the stopper before every entry and discard 28 days after first use.
- Reconstituted peptides: 2–8°C, use within 28 days; avoid freeze-thaw. Volumes: reconstitution calculator.
Full protocols: Storage & Handling Guide · Reconstitution Guide.
Ordering & Pricing — Australia
| Quantity |
Price per unit |
Saving |
| 1–4 units |
$14.95 AUD |
— |
| 5–9 units |
$12.95 AUD |
Save 13% |
| 10+ units |
$10.95 AUD |
Save 27% |
Free priority tracked shipping on orders over $250 AUD. Ships from our Australian warehouse; orders placed before 2pm AEST dispatch same business day. Wholesale enquiries welcome.
Frequently Asked Questions
Which peptides need acetic acid water?
Hydrophobic or aggregation-prone peptides that stay cloudy in bacteriostatic water. In the ClaraScience range that is chiefly AOD-9604 and Tesamorelin. Water-soluble peptides such as BPC-157, TB-500 and Ipamorelin do not need it.
Can I reconstitute entirely in acetic acid water?
It is designed as a first-step solvent. Dissolve the peptide in a small volume of acetic acid water, then top up with bacteriostatic water so the working solution contains the 0.9% benzyl alcohol preservative needed for multi-dose use and sits closer to neutral pH.
Will the acetic acid damage the peptide?
0.6% acetic acid is a mild, standard peptide solvent; dilute acetic acid is routinely used to dissolve peptides that are insoluble in water. Keep the first-step volume small and dilute promptly with bacteriostatic water.
How long does acetic acid water last once opened?
Discard 28 days after the first puncture, stored at room temperature with the stopper swabbed before each entry.
Is acetic acid water available in Australia?
Yes — supplied in 10mL vials from ClaraScience's Australian warehouse, with volume pricing for 5+ and 10+ units. For laboratory research use only — not for human or animal use, and not approved by the TGA for therapeutic use.
